{"type":"standard","title":"Chymotrypsin","displaytitle":"Chymotrypsin","namespace":{"id":0,"text":""},"wikibase_item":"Q383836","titles":{"canonical":"Chymotrypsin","normalized":"Chymotrypsin","display":"Chymotrypsin"},"pageid":7060,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/c/ce/ChymotrypsinA1.jpg","width":250,"height":250},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/c/ce/ChymotrypsinA1.jpg","width":250,"height":250},"lang":"en","dir":"ltr","revision":"1261198723","tid":"f14108ee-b27d-11ef-9f93-f6f53309a22b","timestamp":"2024-12-04T20:25:46Z","description":"Digestive enzyme","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Chymotrypsin","revisions":"https://en.wikipedia.org/wiki/Chymotrypsin?action=history","edit":"https://en.wikipedia.org/wiki/Chymotrypsin?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Chymotrypsin"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Chymotrypsin","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Chymotrypsin","edit":"https://en.m.wikipedia.org/wiki/Chymotrypsin?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Chymotrypsin"}},"extract":"Chymotrypsin (EC 3.4.21.1, chymotrypsins A and B, alpha-chymar ophth, avazyme, chymar, chymotest, enzeon, quimar, quimotrase, alpha-chymar, alpha-chymotrypsin A, alpha-chymotrypsin) is a digestive enzyme component of pancreatic juice acting in the duodenum, where it performs proteolysis, the breakdown of proteins and polypeptides. Chymotrypsin preferentially cleaves peptide amide bonds where the side chain of the amino acid N-terminal to the scissile amide bond (the P1 position) is a large hydrophobic amino acid (tyrosine, tryptophan, and phenylalanine). These amino acids contain an aromatic ring in their side chain that fits into a hydrophobic pocket (the S1 position) of the enzyme. It is activated in the presence of trypsin. The hydrophobic and shape complementarity between the peptide substrate P1 side chain and the enzyme S1 binding cavity accounts for the substrate specificity of this enzyme. Chymotrypsin also hydrolyzes other amide bonds in peptides at slower rates, particularly those containing leucine at the P1 position.","extract_html":"
Chymotrypsin (EC 3.4.21.1, chymotrypsins A and B, alpha-chymar ophth, avazyme, chymar, chymotest, enzeon, quimar, quimotrase, alpha-chymar, alpha-chymotrypsin A, alpha-chymotrypsin) is a digestive enzyme component of pancreatic juice acting in the duodenum, where it performs proteolysis, the breakdown of proteins and polypeptides. Chymotrypsin preferentially cleaves peptide amide bonds where the side chain of the amino acid N-terminal to the scissile amide bond (the P1 position) is a large hydrophobic amino acid (tyrosine, tryptophan, and phenylalanine). These amino acids contain an aromatic ring in their side chain that fits into a hydrophobic pocket (the S1 position) of the enzyme. It is activated in the presence of trypsin. The hydrophobic and shape complementarity between the peptide substrate P1 side chain and the enzyme S1 binding cavity accounts for the substrate specificity of this enzyme. Chymotrypsin also hydrolyzes other amide bonds in peptides at slower rates, particularly those containing leucine at the P1 position.
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